Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 12/20 | 0.51 |
| ▸ | AKT1 | P31749 | 8/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4923512 | 0.90 | RPS6KB1 (0.52) | RPS6KB1AKT1LMNAMAPTHPGD | |
| SCHEMBL4923196 | 0.89 | RPS6KB1 (0.54) | RPS6KB1AKT1LMNAMAPTHPGD | |
| SCHEMBL4931678 | 0.85 | RPS6KB1 (0.49) | RPS6KB1AKT1PDGFRBAKT2RPS6KA3 | |
| SCHEMBL4932837 | 0.84 | RPS6KB1 (0.49) | RPS6KB1AKT1MAPTSMN1; SMN2PDGFRB | |
| SCHEMBL4927697 | 0.83 | RPS6KB1 (0.47) | RPS6KB1AKT1LMNAMAPTHPGD | |
| Trifluoroacetic Acid SCHEMBL4931165 | 0.81 | RPS6KB1 (0.57) | RPS6KB1AKT1LMNAMAPTHPGD | |
| SCHEMBL4926404 | 0.81 | RPS6KB1 (0.43) | RPS6KB1AKT1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL4932132 | 0.80 | RPS6KB1 (0.46) | RPS6KB1AKT1AKT2RPS6KA3 | |
| SCHEMBL4931225 | 0.80 | RPS6KB1 (0.55) | RPS6KB1AKT1MAPTAKT2RPS6KA3 | |
| SCHEMBL4930048 | 0.80 | RPS6KB1 (0.43) | RPS6KB1AKT1SMN1; SMN2PDGFRBCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076338-B2 | Such as 6-(4-phenylpiperazin-1-yl)-9H-purine; cell proliferation/differentiation | EXELIXIS, INC. (US) | 2011-12-13 | — | — | US | disclosed |
| US-20080076774-A1 | Kinase Modulators and Methods of Use | EXELIXIS, INC. (US) | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076774-A1 | Kinase Modulators and Methods of Use | AKT3, RPS6KA3, CDK3 | RPS6KB1 13/4885AKT1 6/4885LMNA 2304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.