Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4938040 | 0.89 | PDE4B (0.50) | PDE4BNR3C1PGRPDE4D | |
| SCHEMBL4940876 | 0.88 | PDE4B (0.49) | PDE4BNR3C1PGRPDE4D | |
| SCHEMBL4940880 | 0.86 | PDE4B (0.48) | PDE4BNR3C1PGRPDE4D | |
| SCHEMBL4937355 | 0.86 | PDE4B (0.55) | PDE4BPDE4D | |
| SCHEMBL4337016 | 0.84 | PDE4B (0.70) | PDE4BNR3C1PGRPDE4D | |
| SCHEMBL4937377 | 0.84 | PDE4B (0.70) | PDE4BPDE4D | |
| SCHEMBL8280506 | 0.82 | PDE4B (0.60) | PDE4B | |
| SCHEMBL4937703 | 0.81 | PDE4B (0.57) | PDE4B | |
| SCHEMBL4937412 | 0.80 | PDE4B (0.58) | PDE4B | |
| SCHEMBL4930318 | 0.79 | PDE4B (0.57) | PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080021058-A1 | Pyrazolo '3,4-B! Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | US | claimed |
| US-20080021058-A1 | Pyrazolo '3,4-B! Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021058-A1 | Pyrazolo '3,4-B! Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors | PDE4A, PDE4B, PDE3B | PDE4B 2/4885NR3C1 84/4885PGR 723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.