Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | CDK8 | P49336 | 2/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 7/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.48 |
| ▸ | RET | P07949 | 3/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | BCR | P11274 | 3/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | MERTK | Q12866 | 2/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.48 |
| ▸ | TEK | Q02763 | 2/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4936491 | 0.87 | SRC (0.60) | ABL1CDK2CDK8CDK1SRC | |
| SCHEMBL4933269 | 0.81 | KDR (0.75) | ABL1CDK2CDK8CDK1SRC | |
| SCHEMBL4937129 | 0.78 | BRAF (0.51) | ABL1SRCRETEGFRKIT | |
| SCHEMBL27745523 | 0.78 | BRAF (0.51) | ABL1SRCRETMAP3K7MAP4K2 | |
| SCHEMBL4938628 | 0.76 | SRC (0.60) | ABL1CDK2CDK8CDK1SRC | |
| SCHEMBL4936336 | 0.75 | CDK2 (0.74) | ABL1CDK2CDK8CDK1SRC | |
| SCHEMBL4936731 | 0.72 | NR1H2 (0.55) | BRAF | |
| SCHEMBL13991087 | 0.71 | KDR (0.70) | ABL1CDK2CDK8CDK1SRC | |
| SCHEMBL4936158 | 0.71 | KDR (0.70) | ABL1CDK2CDK8CDK1SRC | |
| SCHEMBL3183607 | 0.71 | SRC (0.82) | ABL1CDK2CDK8CDK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | RET, PRKDC, PRKACA | ABL1 51/4885CDK2 83/4885CDK8 170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.