Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 20/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.86 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.86 |
| ▸ | PLK3 | Q9H4B4 | 9/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3154915 | 1.00 | PLK1 (0.86) | PLK1CYP3A4CYP2C9PLK3 | |
| SCHEMBL3577545 | 0.93 | PLK1 (0.89) | PLK1CYP3A4CYP2C9PLK3 | |
| SCHEMBL3150935 | 0.93 | PLK1 (1.00) | PLK1CYP3A4CYP2C9PLK3 | |
| SCHEMBL13450938 | 0.93 | PLK1 (1.00) | PLK1CYP3A4CYP2C9PLK3 | |
| SCHEMBL4401446 | 0.92 | PLK1 (0.84) | PLK1CYP3A4CYP2C9PLK3 | |
| SCHEMBL3264829 | 0.91 | PLK1 (0.85) | PLK1CYP3A4CYP2C9PLK3 | |
| SCHEMBL4406023 | 0.88 | PLK1 (0.85) | PLK1CYP3A4CYP2C9PLK3 | |
| SCHEMBL4562031 | 0.88 | PLK1 (0.85) | PLK1CYP3A4CYP2C9PLK3 | |
| SCHEMBL4412008 | 0.88 | PLK1 (0.85) | PLK1CYP3A4CYP2C9PLK3 | |
| SCHEMBL4403532 | 0.88 | PLK1 (0.85) | PLK1CYP3A4CYP2C9PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214563-A1 | Benzimidazole Thiophene Compounds As Plk Modulators | SMITHKLINE BEECHAM CORPORATION | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214563-A1 | Benzimidazole Thiophene Compounds As Plk Modulators | PLK2, PLK3, PLK4 | PLK1 27/4885CYP3A4 146/4885CYP2C9 472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.