Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 9/20 | 0.64 |
| ▸ | JAK3 | P52333 | 9/20 | 0.64 |
| ▸ | SYK | P43405 | 8/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 5/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.51 |
| ▸ | CDK1 | P06493 | 4/20 | 0.49 |
| ▸ | CDK7 | P50613 | 3/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | LYN | P07948 | 2/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138063 | 0.87 | SYK (0.55) | JAK1JAK3SYKADORA3TYRO3 | |
| SCHEMBL4005818 | 0.81 | JAK3 (0.71) | JAK1JAK3SYKCDK2CCNE2 | |
| SCHEMBL17669875 | 0.80 | JAK1 (0.59) | JAK1JAK3SYKCDK2CCNE2 | |
| SCHEMBL4258546 | 0.78 | JAK3 (0.84) | JAK1JAK3SYKTYRO3CDK2 | |
| SCHEMBL1476669 | 0.78 | JAK3 (1.00) | JAK1JAK3SYKCDK2CDK1 | |
| SCHEMBL13166449 | 0.77 | SYK (0.77) | JAK1JAK3SYKCDK2CCNE2 | |
| SCHEMBL4128544 | 0.76 | JAK1 (0.63) | JAK1JAK3SYKCDK2CCNE2 | |
| SCHEMBL4146597 | 0.76 | BRD4 (0.53) | JAK1JAK3SYKADORA3TYRO3 | |
| SCHEMBL3996126 | 0.76 | AURKA (0.67) | JAK1JAK3SYKCDK2CCNE2 | |
| SCHEMBL4356714 | 0.76 | SYK (0.43) | JAK1JAK3SYKADORA3TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306099-A1 | Prevent transplant rejection; autoimmune diseases | RIGEL PHARMACEUTICALS, INC. | 2008-12-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306099-A1 | Prevent transplant rejection; autoimmune diseases | JAK3, JAK1, JAK2 | JAK1 2/4885JAK3 1/4885SYK 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.