Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 4/20 | 0.37 |
| ▸ | CDK9 | P50750 | 3/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930734 | 0.84 | CDC7 (0.40) | KMT2AHASPINCDK9CCNT1CHEK1 | |
| Hydrochloric Acid SCHEMBL5089673 | 0.83 | ADORA2A (0.44) | KMT2AHASPINCDK9CCNT1CHEK1 | |
| Hydrochloric Acid SCHEMBL5089678 | 0.83 | ADORA2A (0.44) | KMT2AHASPINCDK9CCNT1CHEK1 | |
| Hydrochloric Acid SCHEMBL5095245 | 0.83 | ADORA2A (0.44) | KMT2AHASPINCDK9CCNT1CHEK1 | |
| SCHEMBL4928120 | 0.83 | CHEK1 (0.41) | PARP1KMT2AHASPINCDK9CCNT1 | |
| SCHEMBL5571297 | 0.80 | GRM4 (0.41) | GRM4PARP1KMT2ACDK9CCNT1 | |
| SCHEMBL5571291 | 0.80 | GRM4 (0.41) | GRM4PARP1KMT2ACDK9CCNT1 | |
| SCHEMBL4933700 | 0.80 | CDC7 (0.39) | KMT2AHASPINCDK9CCNT1CHEK1 | |
| SCHEMBL4932383 | 0.78 | KMT2A (0.42) | KMT2AHASPINCDK9CCNT1CHEK1 | |
| SCHEMBL4928228 | 0.78 | GSK3B (0.47) | KMT2AHASPINCDK9CCNT1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008516903-A | — | — | 2008-05-22 | — | — | JP | claimed |
| EP-1805175-B1 | NOVEL AZAINDOLE THIAZOLINONES AS ANTI-CANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2008-03-05 | — | — | EP | claimed |
| US-7247727-B2 | Azaindole thiazolinones | HOFFMANN-LA ROCHE INC. (US) | 2007-07-24 | — | — | US | claimed |
| EP-1805175-A1 | NOVEL AZAINDOLE THIAZOLINONES AS ANTI-CANCER AGENTS | F. Hoffmann-Roche AG (CH) | 2007-07-11 | — | — | EP | claimed |
| US-20060084674-A1 | Azaindole thiazolinones | CHEN SHAOQING | 2006-04-20 | — | — | US | claimed |
| WO-2006040049-A1 | NOVEL AZAINDOLE THIAZOLINONES AS ANTI-CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-04-20 | — | — | WO | claimed |
| EP-1805175-B1 | NOVEL AZAINDOLE THIAZOLINONES AS ANTI-CANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2008-03-05 | — | — | EP | disclosed |
| EP-1805175-B1 | NOVEL AZAINDOLE THIAZOLINONES AS ANTI-CANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2008-03-05 | — | — | EP | disclosed |
| US-7247727-B2 | Azaindole thiazolinones | HOFFMANN-LA ROCHE INC. (US) | 2007-07-24 | — | — | US | disclosed |
| US-7247727-B2 | Azaindole thiazolinones | HOFFMANN-LA ROCHE INC. (US) | 2007-07-24 | — | — | US | disclosed |
| US-7247727-B2 | Azaindole thiazolinones | HOFFMANN-LA ROCHE INC. (US) | 2007-07-24 | — | — | US | disclosed |
| EP-1805175-A1 | NOVEL AZAINDOLE THIAZOLINONES AS ANTI-CANCER AGENTS | F. Hoffmann-Roche AG (CH) | 2007-07-11 | — | — | EP | disclosed |
| US-20060084674-A1 | Azaindole thiazolinones | CHEN SHAOQING | 2006-04-20 | — | — | US | disclosed |
| WO-2006040049-A1 | NOVEL AZAINDOLE THIAZOLINONES AS ANTI-CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084674-A1 | Azaindole thiazolinones | CDK1, CDK2, CDK12 | GRM4 3802/4885PARP1 629/4885KMT2A 741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.