Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4935470 | 0.88 | POLB (0.70) | KDM4EMAPTTSHRHSD17B10POLB | |
| SCHEMBL13235187 | 0.84 | MAPT (0.64) | MAPTTSHRHSD17B10POLBALDH1A1 | |
| SCHEMBL4939487 | 0.81 | TSHR (0.61) | KDM4EMAPTTSHRHSD17B10POLB | |
| SCHEMBL13235183 | 0.81 | MAPT (0.58) | MAPTPOLBLMNAKMT2AMEN1 | |
| SCHEMBL4936156 | 0.79 | MAPT (0.66) | MAPTPOLBKMT2ATP53 | |
| SCHEMBL27691404 | 0.79 | MAPT (0.60) | MAPTHSD17B10POLBKMT2ATP53 | |
| SCHEMBL15715997 | 0.77 | MAPT (0.69) | MAPTTSHRHSD17B10POLBALDH1A1 | |
| SCHEMBL4937698 | 0.77 | MAPT (0.55) | MAPTPOLBKMT2ATP53 | |
| SCHEMBL13413797 | 0.76 | HSD17B10 (0.82) | KDM4EMAPTTSHRHSD17B10POLB | |
| SCHEMBL13413798 | 0.74 | MAPT (0.81) | KDM4EMAPTTSHRHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081833-A1 | Novel Pyrazole Derivatives And Their Use As Modulators Of Nicotinic Acetylcholine Receptors | ASTRAZENECA AB (SE) | 2008-04-03 | — | — | US | claimed |
| EP-1831228-A1 | NOVEL PYRAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | claimed |
| WO-2006068591-A1 | NOVEL PYRAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | claimed |
| US-20080081833-A1 | Novel Pyrazole Derivatives And Their Use As Modulators Of Nicotinic Acetylcholine Receptors | ASTRAZENECA AB (SE) | 2008-04-03 | — | — | US | disclosed |
| US-20080081833-A1 | Novel Pyrazole Derivatives And Their Use As Modulators Of Nicotinic Acetylcholine Receptors | ASTRAZENECA AB (SE) | 2008-04-03 | — | — | US | disclosed |
| US-20080081833-A1 | Novel Pyrazole Derivatives And Their Use As Modulators Of Nicotinic Acetylcholine Receptors | ASTRAZENECA AB (SE) | 2008-04-03 | — | — | US | disclosed |
| EP-1831228-A1 | NOVEL PYRAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006068591-A1 | NOVEL PYRAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081833-A1 | Novel Pyrazole Derivatives And Their Use As Modulators Of Nicotinic Acetylcholine Receptors | CHRM2, CHRNA1, CHRM1 | KDM4E 3793/4885MAPT 1368/4885TSHR 234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.