Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.65 |
| ▸ | TNNI3K | Q59H18 | 15/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.65 |
| ▸ | BRAF | P15056 | 11/20 | 0.65 |
| ▸ | RAF1 | P04049 | 4/20 | 0.59 |
| ▸ | STK25 | O00506 | 1/20 | 0.59 |
| ▸ | CIT | O14578 | 1/20 | 0.59 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.59 |
| ▸ | IKBKB | O14920 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | CHUK | O15111 | 1/20 | 0.59 |
| ▸ | MUSK | O15146 | 1/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.59 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4938104 | 0.90 | KDR (0.65) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL4935537 | 0.88 | KDR (0.64) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL4937060 | 0.85 | KDR (0.66) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL22528892 | 0.82 | KDR (0.72) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL4935790 | 0.82 | KDR (0.66) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL4933039 | 0.82 | KDR (0.71) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL3171768 | 0.79 | KDR (1.00) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL4933323 | 0.78 | KDR (0.64) | KDRTNNI3KMAPK14BRAFRAF1 | |
| SCHEMBL12972382 | 0.76 | HTR2C (0.55) | — | |
| SCHEMBL4763945 | 0.75 | KDR (0.86) | KDRTNNI3KMAPK14BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | claimed |
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | RET, PRKDC, PRKACA | KDR 1309/4885TNNI3K 314/4885MAPK14 343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.