Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 5/20 | 0.42 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.42 |
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 4/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4932069 | 0.91 | PIK3CA (0.48) | MTORPIK3CAPIK3CGJAK2JAK3 | |
| SCHEMBL4937545 | 0.90 | JAK2 (0.51) | MTORPIK3CAPIK3CGJAK2JAK3 | |
| SCHEMBL4930763 | 0.90 | PIK3CA (0.48) | MTORPIK3CAPIK3CGJAK2JAK3 | |
| SCHEMBL4940879 | 0.88 | PIK3CA (0.45) | MTORPIK3CAPIK3CGJAK2JAK3 | |
| SCHEMBL4936100 | 0.84 | MTOR (0.48) | MTORPIK3CAPIK3CGRAF1BRAF | |
| SCHEMBL30599038 | 0.84 | MTOR (0.48) | MTORPIK3CAPIK3CGRAF1BRAF | |
| SCHEMBL5182755 | 0.83 | PIK3CA (0.45) | MTORPIK3CAPIK3CGJAK2JAK3 | |
| SCHEMBL4603008 | 0.81 | PIK3CA (0.53) | MTORPIK3CAPIK3CGGBA1GLA | |
| SCHEMBL4938514 | 0.81 | PIK3CA (0.53) | MTORPIK3CAPIK3CGGBA1GLA | |
| SCHEMBL4936958 | 0.80 | PIK3CA (0.54) | MTORPIK3CAPIK3CGJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051401-A1 | 2,4,6-Trisubstituted Pyrimidines as Phosphotidylinositol (Pi) 3-Kinase Inhibitors and Their Use in the Treatment of Cancer | PASS MARTIN | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051401-A1 | 2,4,6-Trisubstituted Pyrimidines as Phosphotidylinositol (Pi) 3-Kinase Inhibitors and Their Use in the Treatment of Cancer | PIK3CA, TYMP, PIK3CB | MTOR 288/4885PIK3CA 1/4885PIK3CG 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.