Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.59 |
| ▸ | BRAF | P15056 | 12/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.59 |
| ▸ | TNNI3K | Q59H18 | 11/20 | 0.59 |
| ▸ | RAF1 | P04049 | 4/20 | 0.59 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.59 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.59 |
| ▸ | CDK2 | P24941 | 2/20 | 0.59 |
| ▸ | CDK8 | P49336 | 2/20 | 0.59 |
| ▸ | STK25 | O00506 | 1/20 | 0.59 |
| ▸ | CIT | O14578 | 1/20 | 0.59 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.59 |
| ▸ | IKBKB | O14920 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | CHUK | O15111 | 1/20 | 0.59 |
| ▸ | MUSK | O15146 | 1/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.59 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4937306 | 0.92 | KDR (0.59) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL4933960 | 0.88 | KDR (0.56) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL13991084 | 0.85 | KDR (0.53) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL3183607 | 0.84 | SRC (0.82) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL4937134 | 0.83 | KDR (0.54) | KDRBRAFMAPK14TNNI3K | |
| SCHEMBL4937815 | 0.83 | SRC (0.69) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL3177365 | 0.83 | KDR (0.61) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL3167291 | 0.82 | KDR (0.74) | KDRBRAFMAPK14TNNI3KRAF1 | |
| SCHEMBL4933180 | 0.82 | KDR (0.57) | KDRBRAFMAPK14TNNI3KRAF1 | |
| Diethylamine SCHEMBL4940356 | 0.81 | KDR (0.56) | KDRBRAFMAPK14TNNI3KRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | claimed |
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | disclosed |
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | disclosed |
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | BOLD GUIDO | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312192-A1 | Diaryl Urea Derivatives in the Treatment of Protein Kinase Dependent Diseases | RET, PRKDC, PRKACA | KDR 1309/4885BRAF 65/4885MAPK14 343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.