Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.49 |
| ▸ | MTOR | P42345 | 6/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4937620 | 0.81 | PIK3CA (0.57) | PIK3CAMTORPIK3CGPIK3CBPIK3CD | |
| SCHEMBL4939462 | 0.79 | PIK3CA (0.55) | PIK3CAMTORPIK3CGPIK3CBPIK3CD | |
| SCHEMBL4938348 | 0.79 | PIK3CA (0.63) | PIK3CAMTORPIK3CGPIK3CBPIK3CD | |
| SCHEMBL4937562 | 0.78 | PIK3CA (0.54) | PIK3CAMTORPIK3CGPIK3CBSMN1; SMN2 | |
| SCHEMBL4936891 | 0.78 | PIK3CA (0.62) | PIK3CAMTORPIK3CGPIK3CBPIK3CD | |
| SCHEMBL4940572 | 0.78 | PIK3CA (0.54) | PIK3CAMTORPIK3CGPIK3CBPIK3CD | |
| SCHEMBL4937645 | 0.76 | PIK3CA (0.61) | PIK3CAMTORPIK3CGPIK3CBPIK3CD | |
| SCHEMBL4932980 | 0.76 | NPC1 (0.54) | PIK3CAMTORPIK3CGPIK3CDRAF1 | |
| SCHEMBL4603463 | 0.76 | NPC1 (0.54) | PIK3CAMTORPIK3CGPIK3CDRAF1 | |
| SCHEMBL4941254 | 0.76 | PIK3CA (0.52) | PIK3CAMTORPIK3CGPIK3CBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051401-A1 | 2,4,6-Trisubstituted Pyrimidines as Phosphotidylinositol (Pi) 3-Kinase Inhibitors and Their Use in the Treatment of Cancer | PASS MARTIN | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051401-A1 | 2,4,6-Trisubstituted Pyrimidines as Phosphotidylinositol (Pi) 3-Kinase Inhibitors and Their Use in the Treatment of Cancer | PIK3CA, TYMP, PIK3CB | NAMPT 549/4885PIK3CA 1/4885MTOR 288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.