Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4935439 | 0.89 | KCNJ6 (0.56) | MAPTPKMMEN1KMT2AALDH1A1 | |
| SCHEMBL4937698 | 0.84 | MAPT (0.55) | MAPTKMT2ATP53POLB | |
| SCHEMBL15716415 | 0.77 | POLB (0.46) | MAPTKMT2ATP53POLBNTRK1 | |
| SCHEMBL13858298 | 0.75 | POLB (0.45) | MAPTKMT2ATP53POLBNTRK1 | |
| SCHEMBL4937639 | 0.73 | KCNJ6 (0.80) | KCNJ6KCNJ3 | |
| SCHEMBL4938366 | 0.73 | KCNJ6 (0.74) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL4104467 | 0.73 | MAPT (0.76) | MAPTPKMMEN1KMT2AKDM4E | |
| SCHEMBL4936156 | 0.73 | MAPT (0.66) | MAPTKMT2ATP53POLBKCNJ6 | |
| SCHEMBL4938012 | 0.72 | MAPT (0.66) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4937742 | 0.72 | POLB (0.70) | MEN1KMT2AGAAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081833-A1 | Novel Pyrazole Derivatives And Their Use As Modulators Of Nicotinic Acetylcholine Receptors | ASTRAZENECA AB (SE) | 2008-04-03 | — | — | US | claimed |
| EP-1831228-A1 | NOVEL PYRAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | claimed |
| WO-2006068591-A1 | NOVEL PYRAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | claimed |
| US-20080081833-A1 | Novel Pyrazole Derivatives And Their Use As Modulators Of Nicotinic Acetylcholine Receptors | ASTRAZENECA AB (SE) | 2008-04-03 | — | — | US | disclosed |
| US-20080081833-A1 | Novel Pyrazole Derivatives And Their Use As Modulators Of Nicotinic Acetylcholine Receptors | ASTRAZENECA AB (SE) | 2008-04-03 | — | — | US | disclosed |
| US-20080081833-A1 | Novel Pyrazole Derivatives And Their Use As Modulators Of Nicotinic Acetylcholine Receptors | ASTRAZENECA AB (SE) | 2008-04-03 | — | — | US | disclosed |
| EP-1440984-B1 | Method of manufacturing water-absorbing shaped body | NIPPON CATALYTIC CHEM IND (JP) | 2007-10-17 | — | — | EP | disclosed |
| EP-1831228-A1 | NOVEL PYRAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006068591-A1 | NOVEL PYRAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |
| US-20040183235-A1 | Method of manufacturing water-absorbing shaped body | NIPPON SHOKUBAI CO., LTD. (JP) | 2004-09-23 | — | — | US | disclosed |
| EP-1440984-A1 | Method of manufacturing water-absorbing shaped body | Nippon Shokubai Co., Ltd. (JP) | 2004-07-28 | — | — | EP | disclosed |
| EP-0801335-B1 | Magnetic coated carrier, two-component type developer and developing method | CANON KK (JP) | 2001-08-29 | — | — | EP | disclosed |
| US-6165663-A | Magnetic coated carrier two-component type developer and developing method | CANON KABUSHIKI KAISHA (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0801335-A1 | Magnetic coated carrier, two-component type developer and developing method | CANON KABUSHIKI KAISHA (JP) | 1997-10-15 | — | — | EP | disclosed |
| EP-0275899-B1 | PROCESS FOR PREPARING PARTICLES HAVING MONODISPERSE PARTICLE SIZE | Nippon Paint Co., Ltd. (JP) | 1991-07-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081833-A1 | Novel Pyrazole Derivatives And Their Use As Modulators Of Nicotinic Acetylcholine Receptors | CHRM2, CHRNA1, CHRM1 | MAPT 1368/4885PKM 1743/4885MEN1 3545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.