Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4937371 | 0.92 | PDE4B (0.55) | PDE4BPDE4DNR3C1 | |
| SCHEMBL4937835 | 0.91 | PDE4B (0.61) | PDE4BPDE4DNR3C1 | |
| SCHEMBL4933800 | 0.90 | PDE4B (0.57) | PDE4BPDE4DNR3C1 | |
| SCHEMBL4931047 | 0.89 | PDE4B (0.56) | PDE4BPDE4DNR3C1 | |
| SCHEMBL4938647 | 0.89 | PDE4B (0.53) | PDE4BPDE4DNR3C1 | |
| SCHEMBL4937411 | 0.88 | PDE4B (0.54) | PDE4BPDE4DNR3C1 | |
| SCHEMBL4939853 | 0.87 | PDE4B (0.57) | PDE4BPDE4DNR3C1 | |
| SCHEMBL4936931 | 0.87 | PDE4B (0.55) | PDE4BPDE4DNR3C1 | |
| SCHEMBL4937628 | 0.87 | PDE4B (0.55) | PDE4BPDE4DNR3C1 | |
| SCHEMBL4937343 | 0.86 | PDE4B (0.54) | PDE4BPDE4DNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275078-A1 | Pyrazolo[3,4-B] Pyridine Compounds and Their Use as Pde4 Inhibitors | GLAXO GROUP LIMITED (GB) | 2008-11-06 | — | — | US | claimed |
| US-20080275078-A1 | Pyrazolo[3,4-B] Pyridine Compounds and Their Use as Pde4 Inhibitors | GLAXO GROUP LIMITED (GB) | 2008-11-06 | — | — | US | disclosed |
| EP-1740590-A1 | PYRAZOLO [3,4- b] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005090354-A1 | PYRAZOLO[3,4-b] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275078-A1 | Pyrazolo[3,4-B] Pyridine Compounds and Their Use as Pde4 Inhibitors | PDE4B, PDE3B, PDE4A | PDE4B 1/4885PDE4D 9/4885NR3C1 964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.