SCHEMBL4943379

SCHEMBL4943379

F[C](F)c1ccc(CN2CCOCC2)cc1Br

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.58
HRH3 Q9Y5N1 2/20 0.50
NCF1 P14598 1/20 0.47
CYP2A13 Q16696 1/20 0.45
CYP2C9 P11712 1/20 0.45
ALOX15 P16050 1/20 0.45
HSD17B10 Q99714 1/20 0.45
NPC1 O15118 3/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
RAB9A P51151 2/20 0.45
TP53 P04637 1/20 0.45
TSHR P16473 1/20 0.45
MAPK1 P28482 1/20 0.45
KDM4E B2RXH2 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
NOS1 P29475 2/20 0.43
HPGD P15428 2/20 0.43
NOS3 P29474 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2376586 0.80 KDM4E (0.68) HTTHRH3NCF1CYP2A13NPC1
SCHEMBL19603235 0.80 HTT (0.62) HTTHRH3NCF1CYP2A13CYP2C9
SCHEMBL30230313 0.80 HTT (0.62) HTTNPC1SMN1; SMN2RAB9ATP53
SCHEMBL4943403 0.78 HTT (0.59) HTTHRH3NCF1CYP2A13NPC1
SCHEMBL1929649 0.77 HTT (0.58) HTTHRH3NCF1CYP2A13CYP2C9
SCHEMBL538318 0.77 HTT (0.58) HTTHRH3NCF1CYP2A13NPC1
SCHEMBL1141938 0.75 HRH3 (0.61) HTTHRH3NCF1CYP2A13NPC1
SCHEMBL28247345 0.73 HTT (0.55) HTTHRH3NCF1NPC1SMN1; SMN2
SCHEMBL19582754 0.73 HTT (0.69) HTTHRH3NCF1CYP2A13NPC1
SCHEMBL29417617 0.73 HTT (0.69) HTTHRH3NCF1CYP2A13NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2008520575-A 2008-06-19 JP claimed
EP-1812012-A2 PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF Ceptyr, Inc. (US) 2007-08-01 EP claimed
WO-2006055525-A2 PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF CEPTYR, INC. (US) 2006-05-26 WO claimed