⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3082306 | 0.73 | — | — | |
| SCHEMBL1070826 | 0.73 | CRBN (0.47) | — | |
| SCHEMBL3253314 | 0.73 | — | — | |
| Diacetamide SCHEMBL28998044 | 0.72 | — | — | |
| Diacetamide SCHEMBL97089 | 0.71 | — | — | |
| SCHEMBL8935555 | 0.71 | — | — | |
| SCHEMBL5841052 | 0.71 | — | — | |
| SCHEMBL4943730 | 0.69 | — | — | |
| SCHEMBL18099867 | 0.69 | — | — | |
| Acetylguanidinium SCHEMBL79062 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354946-B2 | prominent growth inhibitory activity against tumor cells; cyclin dependent kinase inhibitors; colon cancer; N'-(3-t-butylisoindolino[3,2-b]oxazolidin-4-on-8-yl)-N-(4-(N-benzylpyrrolidin-3-yl)pyridin-2-yl)urea | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-04-08 | — | — | US | disclosed |
| US-20070027147-A1 | Biarylurea derivatives | MSD K.K. (JP) | 2007-02-01 | — | — | US | disclosed |
| EP-1199306-B1 | BIARYLUREA DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2005-12-07 | — | — | EP | disclosed |
| US-6958333-B1 | Biarylurea derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-10-25 | — | — | US | disclosed |
| EP-1557168-A2 | Biarylurea Derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-07-27 | — | — | EP | disclosed |
| EP-1199306-A1 | BIARYLUREA DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2002-04-24 | — | — | EP | disclosed |