Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 7/20 | 0.48 |
| ▸ | PPARG | P37231 | 5/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 8/20 | 0.44 |
| ▸ | PPARD | Q03181 | 4/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4943528 | 1.00 | PPARA (0.48) | PPARAPPARGSLC6A9PPARDCYP1A1 | |
| SCHEMBL4939476 | 0.88 | PPARA (0.60) | PPARAPPARGSLC6A9PPARDCYP1A1 | |
| SCHEMBL4939482 | 0.88 | PPARA (0.60) | PPARAPPARGSLC6A9PPARDCYP1A1 | |
| SCHEMBL4940757 | 0.85 | PPARA (0.45) | PPARAPPARGPPARDMAOB | |
| SCHEMBL4940760 | 0.85 | PPARA (0.45) | PPARAPPARGPPARDMAOB | |
| SCHEMBL4942052 | 0.82 | PPARG (0.45) | PPARAPPARGSLC6A9PPARDCYP1A1 | |
| SCHEMBL4940963 | 0.78 | PPARA (0.39) | PPARAPPARGPPARDPTPN1 | |
| SCHEMBL4940962 | 0.78 | PPARA (0.39) | PPARAPPARGPPARDPTPN1 | |
| SCHEMBL21991735 | 0.78 | PPARG (0.48) | PPARAPPARGSLC6A9PPARDCYP1A1 | |
| SCHEMBL11361509 | 0.77 | PPARG (0.52) | PPARAPPARGSLC6A9PPARDCYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194608-A1 | 6-Phenylhex-5-Enoic Acid Derivatives, Process for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Uses Thereof | MERCK PATENT GMBH (DE) | 2008-08-14 | — | — | US | disclosed |
| EP-1838655-A1 | 6-PHENYLHEX-5-ENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC USES THEREOF | Merck Patent GmbH (DE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006074797-A1 | 6-PHENYLHEX-5-ENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC USES THEREOF | MERCK PATENT GMBH (DE) | 2006-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194608-A1 | 6-Phenylhex-5-Enoic Acid Derivatives, Process for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Uses Thereof | PCSK9, HMGCR, LIPA | PPARA 56/4885PPARG 178/4885SLC6A9 4248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.