Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4943971 | 1.00 | HRH3 (0.76) | HRH3KCNH2KDM2B | |
| SCHEMBL3722220 | 0.93 | HRH3 (0.76) | HRH3KCNH2KDM2B | |
| SCHEMBL3722222 | 0.93 | HRH3 (0.76) | HRH3KCNH2KDM2B | |
| SCHEMBL4941875 | 0.89 | HRH3 (0.79) | HRH3KCNH2 | |
| SCHEMBL3672593 | 0.89 | HRH3 (0.79) | HRH3KCNH2 | |
| SCHEMBL4941881 | 0.89 | HRH3 (0.79) | HRH3KCNH2 | |
| SCHEMBL3672590 | 0.89 | HRH3 (0.79) | HRH3KCNH2 | |
| SCHEMBL3727192 | 0.86 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL3726435 | 0.86 | HRH3 (0.75) | HRH3KCNH2 | |
| SCHEMBL3726432 | 0.86 | HRH3 (0.75) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293771-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-11-27 | — | — | US | claimed |
| US-20080293771-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293771-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | HRH4, HRH3, HRH2 | HRH3 2/4885KCNH2 581/4885KDM2B 456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.