Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | SHBG | P04278 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30506519 | 0.81 | MEN1 (0.54) | FFAR1GRM2SHBG | |
| SCHEMBL4937297 | 0.81 | MEN1 (0.54) | FFAR1GRM2SHBG | |
| SCHEMBL481119 | 0.80 | HSP90AB1 (0.52) | PIK3CASHBG | |
| SCHEMBL1831691 | 0.79 | FFAR1 (0.47) | FFAR1GRM2 | |
| SCHEMBL4943475 | 0.79 | GRM2 (0.54) | FFAR1GRM2 | |
| SCHEMBL6354449 | 0.78 | FFAR1 (0.50) | FFAR1GRM2 | |
| SCHEMBL32679233 | 0.76 | FFAR1 (0.44) | FFAR1GRM2PIK3CA | |
| SCHEMBL32679234 | 0.76 | FFAR1 (0.44) | FFAR1GRM2PIK3CA | |
| SCHEMBL1831012 | 0.76 | FFAR1 (0.44) | FFAR1GRM2PIK3CA | |
| SCHEMBL6358047 | 0.76 | GRM2 (0.46) | FFAR1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293684-A1 | Heterocyclic Acetophenone Potentiators of Metabotropic Glutamate Receptors | MERCK SHARP & DOHME CORP. | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293684-A1 | Heterocyclic Acetophenone Potentiators of Metabotropic Glutamate Receptors | GRM2, GRM1, GRIK2 | FFAR1 138/4885GRM2 1/4885PIK3CA 2770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.