Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 20/20 | 0.55 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.54 |
| ▸ | HRH1 | P35367 | 4/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3575532 | 0.93 | SSTR5 (0.56) | SSTR5SSTR1HRH1HTR2BKCNH2 | |
| SCHEMBL3571138 | 0.85 | SSTR5 (0.71) | SSTR5SSTR1HRH1HTR2BKCNH2 | |
| SCHEMBL3583358 | 0.84 | SSTR5 (0.74) | SSTR5HRH1HTR2B | |
| SCHEMBL3580849 | 0.84 | SSTR5 (0.71) | SSTR5SSTR1HRH1HTR2BKCNH2 | |
| SCHEMBL3571483 | 0.84 | SSTR5 (0.71) | SSTR5SSTR1HRH1HTR2BKCNH2 | |
| SCHEMBL3569623 | 0.84 | SSTR5 (0.71) | SSTR5SSTR1HRH1HTR2B | |
| SCHEMBL3583899 | 0.81 | SSTR5 (0.58) | SSTR5SSTR1HRH1HTR2BKCNH2 | |
| SCHEMBL3579228 | 0.80 | SSTR5 (0.69) | SSTR5SSTR1HRH1HTR2BKCNH2 | |
| SCHEMBL3577223 | 0.78 | SSTR5 (0.78) | SSTR5SSTR1HRH1KCNH2 | |
| SCHEMBL3578460 | 0.78 | SSTR5 (0.70) | SSTR5SSTR1HRH1HTR2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-B1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | EP | disclosed |
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |