Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 20/20 | 0.69 |
| ▸ | HRH1 | P35367 | 5/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3568958 | 0.95 | SSTR5 (0.75) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4956546 | 0.90 | SSTR5 (0.73) | SSTR5HRH1SSTR1KCNH2 | |
| SCHEMBL4952835 | 0.88 | SSTR5 (0.77) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4949587 | 0.88 | SSTR5 (0.72) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4950476 | 0.87 | SSTR5 (0.76) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4954309 | 0.87 | SSTR5 (0.91) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4955606 | 0.87 | SSTR5 (0.76) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4952224 | 0.87 | SSTR5 (0.78) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4949004 | 0.85 | SSTR5 (0.78) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL3575453 | 0.85 | SSTR5 (0.80) | SSTR5HRH1SSTR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101137660-B | Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives as antidiabetic compounds | HOFFMANN LA ROCHE | 2011-06-15 | — | — | CN | disclosed |
| EP-1858901-B1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | EP | disclosed |
| CN-101137660-A | Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives as antidiabetic compounds | HOFFMANN LA ROCHE (CH) | 2008-03-05 | — | — | CN | disclosed |