SCHEMBL4948820

SCHEMBL4948820

Nc1ncnc(-c2ccncc2)n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 2/20 0.42
ADORA1 P30542 2/20 0.42
HRH4 Q9H3N8 1/20 0.41
PIK3CD O00329 1/20 0.41
PIK3CA P42336 1/20 0.41
PIK3CB P42338 1/20 0.41
PIK3CG P48736 1/20 0.41
MAPT P10636 3/20 0.40
LMNA P02545 2/20 0.40
MAP4K4 O95819 1/20 0.40
POLB P06746 1/20 0.39
ADORA3 P0DMS8 1/20 0.39
ADORA2B P29275 1/20 0.39
NPC1 O15118 2/20 0.39
CYP19A1 P11511 1/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
HSP90AA1 P07900 2/20 0.37
MEN1 O00255 1/20 0.37
ALDH1A1 P00352 1/20 0.37
CYP2D6 P10635 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31528318 1.00 ADORA2A (0.42) ADORA2AADORA1HRH4PIK3CDPIK3CA
SCHEMBL18731945 0.84 MAPT (0.50) PIK3CDPIK3CAPIK3CBPIK3CGMAPT
SCHEMBL8744265 0.81 NPC1 (0.48) ADORA2AADORA1PIK3CDPIK3CAPIK3CB
SCHEMBL31461473 0.81 ADORA2A (0.61) ADORA2AADORA1HRH4MAPTPOLB
SCHEMBL3421908 0.81 ADORA2A (0.61) ADORA2AADORA1HRH4MAPTPOLB
SCHEMBL9791640 0.78 ADORA2A (0.62) ADORA2AADORA1HRH4MAPTLMNA
SCHEMBL8490725 0.78 ADORA2A (0.56) ADORA2AADORA1HRH4MAPTLMNA
SCHEMBL28606940 0.78 ADORA2A (0.57) ADORA2AADORA1MAPTMAP4K4POLB
SCHEMBL31366845 0.78 SMN1; SMN2 (0.51) ADORA2AADORA1HRH4PIK3CAMAP4K4
SCHEMBL19055491 0.77 HSP90AA1 (0.57) MAPTLMNAPOLBCYP19A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3185330-B1 ORGANIC LIGHT-EMITTING DEVICE SAMSUNG DISPLAY CO LTD (KR) 2023-08-16 EP disclosed
EP-3246963-B1 ORGANIC LIGHT-EMITTING DEVICE SAMSUNG DISPLAY CO LTD (KR) 2023-05-31 EP disclosed
EP-3663283-B1 CONDENSED CYCLIC COMPOUND, COMPOSITION INCLUDING THE SAME, AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THIN FILM FORMED FROM THE COMPOSITION SAMSUNG DISPLAY CO LTD (KR) 2021-11-03 EP disclosed
CN-104114543-B Therapeutically active compounds and methods of use thereof 安吉奥斯医药品有限公司 2019-03-15 CN disclosed
EP-3301097-A2 [1]BENZOTHIENO[3',2':4,5]IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN ORGANIC LIGHT-EMITTING DEVICES (OLEDS) Samsung Display Co., Ltd. (KR) 2018-04-04 EP disclosed
EP-3185328-A1 ORGANIC LIGHT-EMITTING DEVICE Samsung Display Co., Ltd. (KR) 2017-06-28 EP disclosed
EP-1218360-B1 TRIAZINE KINASE INHIBITORS AMGEN INC (US) 2008-05-28 EP disclosed
EP-1218360-B1 TRIAZINE KINASE INHIBITORS AMGEN INC (US) 2008-05-28 EP disclosed
US-7074789-B2 Kinase inhibitors AMGEN INC. (US) 2006-07-11 US disclosed
US-20040116388-A1 triazine compoound inhibitors of enzymes that catalyze phosphoryl transfer and/or that bind ATP/GTP nucleotides AMGEN INC. 2004-06-17 US disclosed
EP-1218360-A1 TRIAZINE KINASE INHIBITORS Amgen Inc., (US) 2002-07-03 EP disclosed
WO-2001025220-A1 TRIAZINE KINASE INHIBITORS AMGEN INC. (US) 2001-04-12 WO disclosed