Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 19/20 | 0.81 |
| ▸ | HRH1 | P35367 | 7/20 | 0.81 |
| ▸ | HTR2B | P41595 | 2/20 | 0.81 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582082 | 0.92 | SSTR5 (0.87) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4944653 | 0.90 | SSTR5 (0.80) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4951995 | 0.90 | SSTR5 (0.80) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4944799 | 0.90 | SSTR5 (0.82) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4952336 | 0.90 | SSTR5 (0.81) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL3573210 | 0.89 | SSTR5 (1.00) | SSTR5HRH1HTR2B | |
| SCHEMBL4947648 | 0.89 | SSTR5 (0.83) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL3633290 | 0.88 | SSTR5 (1.00) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL4947594 | 0.88 | SSTR5 (0.80) | SSTR5HRH1HTR2BSSTR1KCNH2 | |
| SCHEMBL1379959 | 0.88 | SSTR5 (0.87) | SSTR5HRH1HTR2BSSTR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-B1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | EP | claimed |
| EP-1858901-B1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | EP | disclosed |