Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4947825 | 0.89 | HRH3 (0.44) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4950777 | 0.89 | HRH3 (0.45) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4950151 | 0.88 | HRH3 (0.44) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4949632 | 0.88 | HRH3 (0.44) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4952441 | 0.85 | HRH3 (0.44) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4949845 | 0.84 | HRH3 (0.43) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4949370 | 0.83 | HRH3 (0.46) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4948641 | 0.83 | HRH3 (0.45) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4949505 | 0.83 | HRH3 (0.44) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4947619 | 0.83 | GRIN2D (0.51) | HRH3GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828134-B1 | PIPERAZINYL PYRIDINE DERIVATIVES AS ANTI-OBESITY AGENTS | HOFFMANN LA ROCHE (CH) | 2008-10-29 | — | — | EP | claimed |