Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | MYC | P01106 | 1/20 | 0.58 |
| ▸ | MAX | P61244 | 1/20 | 0.58 |
| ▸ | CLK1 | P49759 | 3/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.56 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.56 |
| ▸ | MTOR | P42345 | 2/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496964 | 1.00 | MAPT (0.62) | MAPTALDH1A1GAAMYCMAX | |
| SCHEMBL496962 | 1.00 | MAPT (0.62) | MAPTALDH1A1GAAMYCMAX | |
| SCHEMBL4944702 | 0.85 | MAPT (0.56) | MAPTALDH1A1GAAMYCMAX | |
| SCHEMBL497003 | 0.85 | MAPT (0.56) | MAPTALDH1A1GAAMYCMAX | |
| SCHEMBL497004 | 0.85 | MAPT (0.56) | MAPTALDH1A1GAAMYCMAX | |
| SCHEMBL14437313 | 0.79 | MYC (0.53) | MAPTALDH1A1GAAMYCMAX | |
| SCHEMBL5503992 | 0.79 | MYC (0.53) | MAPTALDH1A1GAAMYCMAX | |
| SCHEMBL5503991 | 0.79 | MYC (0.53) | MAPTALDH1A1GAAMYCMAX | |
| SCHEMBL3865325 | 0.79 | MAPT (0.55) | MAPTALDH1A1GAAMYCMAX | |
| SCHEMBL3865324 | 0.79 | MAPT (0.55) | MAPTALDH1A1GAAMYCMAX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885362-A2 | NOVEL CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006127458-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-30 | — | — | WO | disclosed |