Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14115622 | 0.82 | GRM2 (0.54) | GRM2ALOX5KCNH2 | |
| SCHEMBL758425 | 0.81 | GRM2 (0.55) | GRM2ALOX5KCNH2 | |
| SCHEMBL755623 | 0.80 | GRM2 (0.54) | GRM2ALOX5KCNH2 | |
| SCHEMBL2004669 | 0.80 | IDO1 (0.50) | GRM2MEN1KMT2ACA12CA9 | |
| SCHEMBL758398 | 0.80 | GRM2 (0.59) | GRM2ALOX5KCNH2 | |
| SCHEMBL757893 | 0.79 | GRM2 (0.67) | GRM2ALOX5KCNH2 | |
| SCHEMBL755783 | 0.79 | GRM2 (0.67) | GRM2ALOX5KCNH2 | |
| SCHEMBL1997326 | 0.78 | MAOB (0.42) | GRM2CA12CA9MAOB | |
| SCHEMBL756043 | 0.77 | CA12 (0.47) | ALOX5MEN1KMT2ACA12CA9 | |
| SCHEMBL2004788 | 0.76 | GRM2 (0.48) | GRM2ALOX5KCNH2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008095292-A1 | [1,2,3] TRIAZOLYL SUBSTITUTED QUINOLINES AND COUMARINS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA LTD. (CA) | 2008-08-14 | — | — | WO | claimed |