Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | S100A4 | P26447 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4954274 | 1.00 | MAPT (0.62) | MAPTPTGS2MAOBALDH1A1LMNA | |
| SCHEMBL4954257 | 1.00 | MAPT (0.62) | MAPTPTGS2MAOBALDH1A1LMNA | |
| SCHEMBL29134667 | 0.88 | MAPT (0.62) | MAPTMAOBALDH1A1LMNAHSP90AA1 | |
| SCHEMBL29134666 | 0.88 | MAPT (0.62) | MAPTMAOBALDH1A1LMNAHSP90AA1 | |
| SCHEMBL3602553 | 0.83 | MAPT (0.64) | MAPTPTGS2MAOBALDH1A1KMT2A | |
| SCHEMBL989659 | 0.83 | MAPT (0.64) | MAPTPTGS2MAOBALDH1A1KMT2A | |
| SCHEMBL10780080 | 0.83 | MAPT (0.64) | MAPTPTGS2MAOBALDH1A1LMNA | |
| SCHEMBL9658637 | 0.83 | MAPT (0.64) | MAPTPTGS2MAOBKMT2AMEN1 | |
| SCHEMBL9658649 | 0.83 | MAPT (0.64) | MAPTPTGS2MAOBKMT2AMEN1 | |
| SCHEMBL1174503 | 0.83 | MAPT (0.64) | MAPTPTGS2MAOBALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009002955-A1 | PROCESS FOR THE PREPARATION OF (2R)-2-[4-(7-BROMO-2-QUINOLYLOXY)PHENOXY]PROPANOIC ACID | SANOFI-AVENTIS U.S. LLC (US) | 2008-12-31 | — | — | WO | disclosed |