Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Enalaprilat Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 13/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Enalaprilat Anhydrous SCHEMBL37288 | 1.00 | ACE (0.98) | ACELMNASMN1; SMN2 | |
| Enalaprilat Anhydrous SCHEMBL8149345 | 1.00 | ACE (0.98) | ACELMNASMN1; SMN2 | |
| Enalaprilat Anhydrous SCHEMBL21046169 | 1.00 | ACE (0.98) | ACELMNASMN1; SMN2 | |
| Enalaprilat Anhydrous SCHEMBL8903287 | 0.99 | ACE (0.96) | ACELMNASMN1; SMN2 | |
| Enalaprilat Anhydrous SCHEMBL8836365 | 0.99 | ACE (0.96) | ACELMNASMN1; SMN2 | |
| Enalaprilat Anhydrous SCHEMBL24327564 | 0.99 | ACE (1.00) | ACELMNASMN1; SMN2 | |
| Enalaprilat Anhydrous SCHEMBL3090322 | 0.99 | ACE (1.00) | ACELMNASMN1; SMN2 | |
| Enalaprilat Anhydrous SCHEMBL6106603 | 0.99 | ACE (1.00) | ACELMNASMN1; SMN2 | |
| Enalaprilat Anhydrous SCHEMBL12737170 | 0.99 | ACE (1.00) | ACELMNASMN1; SMN2 | |
| Enalaprilat Anhydrous SCHEMBL2406720 | 0.99 | ACE (1.00) | ACELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390789-B2 | Thio-containing inhibitors of aminopeptidase P, and compositions thereof | SIMMONS WILLIAM H | 2008-06-24 | — | — | US | disclosed |
| US-20070060525-A1 | Thio-containing inhibitors of aminopeptidase P, compositions thereof and method of use | SIMMONS WILLIAM H | 2007-03-15 | — | — | US | disclosed |
| EP-0835123-A4 | AMINOPEPTIDASE P INHIBITORS AND USES THEREOF | UNIV LOYOLA CHICAGO (US) | 2001-05-16 | — | — | EP | disclosed |
| US-6087386-A | A BILAYER OR TRILAYER TABLET DOSE FORM COMPRISING A FIRST ENALAPRIL LAYER AND A SECOND LOSARTAN LAYER FOR THE COADMINISTRATION OF AN ACE INIHIBITOR WITH AN AII ANTAGONIST; TREATING HYPERTENSION AND CONGESTIVE HEART FAILUR | MERCK & CO., INC. (US) | 2000-07-11 | — | — | US | disclosed |
| EP-0910375-A4 | A COMPOSITION OF ENALAPRIL AND LOSARTAN | MERCK & CO INC (US) | 1999-09-01 | — | — | EP | disclosed |
| EP-0910375-A1 | A COMPOSITION OF ENALAPRIL AND LOSARTAN | Merck & Co., Inc. (US) | 1999-04-28 | — | — | EP | disclosed |
| EP-0835123-A1 | AMINOPEPTIDASE P INHIBITORS AND USES THEREOF | LOYOLA UNIVERSITY OF CHICAGO (US) | 1998-04-15 | — | — | EP | disclosed |
| WO-1997049392-A1 | A COMPOSITION OF ENALAPRIL AND LOSARTAN | MERCK & CO., INC. (US) | 1997-12-31 | — | — | WO | disclosed |
| US-5656603-A | INHIBITING BRANDYKININ DEGRADATION | LOYOLA UNIVERSITY OF CHICAGO (US) | 1997-08-12 | — | — | US | disclosed |
| WO-1996039163-A1 | AMINOPEPTIDASE P INHIBITORS AND USES THEREOF | LOYOLA UNIVERSITY OF CHICAGO (US) | 1996-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060525-A1 | Thio-containing inhibitors of aminopeptidase P, compositions thereof and method of use | ACE, DNPEP, APP | ACE 1/4885LMNA 2230/4885SMN1; SMN2 4342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.