Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.45 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4956185 | 0.86 | HDAC3 (0.47) | PTPN1PTPN2PTGER3RAB9AKDM4E | |
| SCHEMBL4955427 | 0.82 | PTPN1 (0.42) | PTPN1PTPN2PTGER3RAB9AKDM4E | |
| SCHEMBL4957975 | 0.82 | PTPN1 (0.50) | PTPN1PTPN2PTGS2RAB9AMEN1 | |
| SCHEMBL4957727 | 0.79 | PTPN1 (0.48) | PTPN1PTPN2RAB9AMEN1KMT2A | |
| SCHEMBL4957186 | 0.79 | PTPN1 (0.48) | PTPN1PTPN2RAB9AMEN1KMT2A | |
| SCHEMBL4955550 | 0.77 | PTPN1 (0.45) | PTPN1PTPN2RAB9AMEN1KMT2A | |
| SCHEMBL4959758 | 0.77 | PTPN1 (0.49) | PTPN1PTPN2PTGS2RAB9AKDM4E | |
| SCHEMBL5274387 | 0.77 | MEN1 (0.46) | PTPN1PTPN2RAB9AKDM4EMEN1 | |
| SCHEMBL4954888 | 0.77 | PTPN1 (0.48) | PTPN1PTPN2RAB9AKDM4EALDH1A1 | |
| SCHEMBL4954863 | 0.77 | PTPN1 (0.46) | PTPN1PTPN2RAB9AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200371-A1 | THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | IMPINJ, INC. | 2008-08-21 | — | — | US | claimed |
| EP-1841749-A1 | DERIVATIVES OF THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | Metabasis Therapeutics, Inc. (US) | 2007-10-10 | — | — | EP | claimed |
| US-20060194768-A1 | Thiazole and thiadiazole inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2006-08-31 | — | — | US | claimed |
| WO-2006028970-A1 | DERIVATIVES OF THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | CENGENT THERAPEUTICS, INC. (US) | 2006-03-16 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194768-A1 | Thiazole and thiadiazole inhibitors of tyrosine phosphatases | PTPN1, PTPN5, PTPN18 | PTPN1 1/4885PTPN2 6/4885PTGER3 2979/4885 |
| US-20080200371-A1 | THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | PTPN1, PTPN5, PTPN18 | PTPN1 1/4885PTPN2 6/4885PTGER3 2979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.