Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 10/20 | 0.34 |
| ▸ | IL2 | P60568 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | PIP5K1C | O60331 | 2/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.30 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.30 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4948590 | 0.88 | AURKA (0.46) | AURKAAURKBFLT3CHEK1SRC | |
| SCHEMBL4948961 | 0.79 | AURKA (0.53) | AURKAAURKBFLT3CHEK1SRC | |
| SCHEMBL4949158 | 0.78 | AURKA (0.42) | AURKAAURKBFLT3CDK2GSK3B | |
| SCHEMBL4943760 | 0.76 | AURKA (0.50) | AURKAAURKBFLT3CHEK1SRC | |
| SCHEMBL4943724 | 0.76 | AURKA (0.50) | AURKAAURKBFLT3CHEK1SRC | |
| SCHEMBL4946028 | 0.75 | AURKA (0.61) | AURKAAURKBFLT3CHEK1SRC | |
| SCHEMBL4948192 | 0.75 | AURKA (0.58) | AURKAAURKBFLT3CHEK1SRC | |
| SCHEMBL4947391 | 0.75 | AURKA (0.47) | AURKAAURKBFLT3CHEK1SRC | |
| SCHEMBL4944597 | 0.74 | AURKA (0.56) | AURKAAURKBFLT3CHEK1SRC | |
| SCHEMBL4946007 | 0.74 | AURKA (0.49) | AURKAAURKBFLT3CHEK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885725-B1 | TRICYCLIC AZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-09-24 | — | — | EP | claimed |