Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.50 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | PER2 | O15055 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.44 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.44 |
| ▸ | LAP3 | P28838 | 5/20 | 0.43 |
| ▸ | ANPEP | P15144 | 2/20 | 0.43 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.43 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL497123 | 0.99 | SPPL2A (0.49) | SPPL2ACSNK1EF2PER2ALDH1A1 | |
| SCHEMBL14390723 | 0.86 | SPPL2A (0.54) | SPPL2ACSNK1EF2ALDH1A1LAP3 | |
| SCHEMBL14508161 | 0.82 | SPPL2A (0.65) | SPPL2ACSNK1EF2PER2ALDH1A1 | |
| SCHEMBL496237 | 0.81 | CSNK1E (0.55) | SPPL2ACSNK1ELAP3ANPEPRNPEP | |
| SCHEMBL26941825 | 0.80 | CSNK1E (0.51) | SPPL2ACSNK1EF2LAP3ANPEP | |
| Hydrochloric Acid SCHEMBL496260 | 0.80 | CSNK1E (0.54) | SPPL2ACSNK1ELAP3ANPEPRNPEP | |
| Hydrochloric Acid SCHEMBL15062952 | 0.80 | CSNK1E (0.54) | SPPL2ACSNK1ELAP3ANPEPRNPEP | |
| Hydrochloric Acid SCHEMBL4789127 | 0.80 | CSNK1E (0.54) | SPPL2ACSNK1ELAP3ANPEPRNPEP | |
| SCHEMBL5106607 | 0.78 | CSNK1E (0.49) | SPPL2ACSNK1ELAP3ANPEPRNPEP | |
| SCHEMBL13118762 | 0.77 | SPPL2A (0.53) | SPPL2ACSNK1ELAP3ANPEPRNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910317-B1 | 1-AMINO LINKED COMPOUNDS | LILLY CO ELI (US) | 2013-07-03 | — | — | EP | disclosed |
| EP-1910317-B1 | 1-AMINO LINKED COMPOUNDS | LILLY CO ELI (US) | 2013-07-03 | — | — | EP | disclosed |
| US-8106090-B2 | Antidiabetic agents; prevent of non-insulin dependent diabetes | ELI LILLY AND COMPANY (US) | 2012-01-31 | — | — | US | disclosed |
| US-8106090-B2 | Antidiabetic agents; prevent of non-insulin dependent diabetes | ELI LILLY AND COMPANY (US) | 2012-01-31 | — | — | US | disclosed |
| US-20080207735-A1 | 1-Amino Linked Compounds | ELI LILLY AND COMPANY | 2008-08-28 | — | — | US | disclosed |
| US-20080207735-A1 | 1-Amino Linked Compounds | ELI LILLY AND COMPANY | 2008-08-28 | — | — | US | disclosed |
| WO-2007015805-A1 | 1-AMINO LINKED COMPOUNDS | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207735-A1 | 1-Amino Linked Compounds | DPP4, DPP3, DPP9 | SPPL2A 2493/4885CSNK1E 194/4885F2 3381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.