Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 8/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.43 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Lactic Acid SCHEMBL4956635 | 0.86 | CHRM1 (0.42) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Bicarbonate SCHEMBL29201465 | 0.84 | CHRM1 (0.52) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Lactic Acid SCHEMBL28158391 | 0.82 | TP53 (0.61) | TP53TSHR | |
| Bicarbonate SCHEMBL29201353 | 0.80 | CHRM1 (0.48) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL27614905 | 0.80 | CHRM1 (0.73) | TP53CHRM1CHRM3CHRM2CHRM4 | |
| Lactic Acid SCHEMBL27571251 | 0.78 | TP53 (0.55) | TP53LMNAMAPTMAPK1 | |
| Pivalate SCHEMBL29196174 | 0.77 | CHRM1 (0.45) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Methoxyacetic Acid SCHEMBL28141852 | 0.77 | CHRM1 (0.45) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL265151 | 0.76 | — | — | |
| Choline SCHEMBL3820379 | 0.76 | MEN1 (0.55) | TP53CHRM1CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7455903-B2 | Optical materials and optical elements using the same | FUJI XEROX CO., LTD. (JP) | 2008-11-25 | — | — | US | disclosed |
| US-20060121285-A1 | Optical materials and optical elements using the same | FUJI XEROX CO., LTD. | 2006-06-08 | — | — | US | disclosed |