Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.59 |
| ▸ | MAP3K8 | P41279 | 10/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.50 |
| ▸ | SRC | P12931 | 4/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.50 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | PRKCB | P05771 | 1/20 | 0.50 |
| ▸ | PRKCA | P17252 | 1/20 | 0.50 |
| ▸ | PRKCH | P24723 | 1/20 | 0.50 |
| ▸ | PRKCI | P41743 | 1/20 | 0.50 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.50 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.50 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.50 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.50 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963176 | 0.88 | EGFR (0.54) | EGFRERBB2MAP3K8MAPK13SRC | |
| SCHEMBL4964021 | 0.83 | MAP3K8 (0.64) | EGFRMAP3K8MAPK13SRCMAPK12 | |
| SCHEMBL4774110 | 0.81 | MAP3K8 (0.74) | EGFRERBB2MAP3K8MAPK13SRC | |
| SCHEMBL4960758 | 0.77 | MAP3K8 (0.61) | EGFRERBB2MAP3K8MAPK13MAPK12 | |
| SCHEMBL6071744 | 0.77 | MAP3K8 (0.55) | EGFRERBB2MAP3K8MAPK13SRC | |
| SCHEMBL4961565 | 0.76 | EGFR (0.58) | EGFRERBB2 | |
| SCHEMBL6379750 | 0.76 | EGFR (0.60) | EGFRERBB2SRCMAP2K1 | |
| SCHEMBL6382853 | 0.76 | EGFR (0.58) | EGFRERBB2SRCMAP2K1 | |
| SCHEMBL6383845 | 0.75 | EGFR (1.00) | EGFRERBB2 | |
| SCHEMBL4959649 | 0.74 | MAP3K8 (0.73) | EGFRERBB2MAP3K8MAPK13SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101223143-A | 3-cyanoquinoline inhibitors of TPL2 kinase and methods of making and using the same | WYETH CORP (US) | 2008-07-16 | — | — | CN | disclosed |
| EP-1888529-A2 | 3-CYANOQUINOLINE INHIBITORS OF TPL2 KINASE AND METHODS OF MAKING AND USING THE SAME | Wyeth (US) | 2008-02-20 | — | — | EP | disclosed |
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
| WO-2006124692-A2 | 3-CYANOQUINOLINE INHIBITORS OF TPL2 KINASE AND METHODS OF MAKING AND USING THE SAME | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264460-A1 | 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same | TNNI3K, CSNK1A1L, CDKL1 | EGFR 4122/4885ERBB2 1721/4885MAP3K8 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.