Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.59 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4959978 | 1.00 | KDM4E (0.70) | KDM4EGAASMN1; SMN2HTTNCOA1 | |
| SCHEMBL31665065 | 0.85 | KDM4E (0.62) | KDM4EGAASMN1; SMN2HTTNCOA1 | |
| SCHEMBL4958310 | 0.84 | GAA (0.71) | GAASMN1; SMN2HTTNCOA1NCOA3 | |
| SCHEMBL4958300 | 0.84 | GAA (0.71) | GAASMN1; SMN2HTTNCOA1NCOA3 | |
| SCHEMBL6108383 | 0.82 | HTT (0.61) | KDM4EGAASMN1; SMN2HTTNCOA1 | |
| SCHEMBL4859758 | 0.82 | KDM4E (1.00) | KDM4EGAASMN1; SMN2HTTNCOA1 | |
| SCHEMBL31665600 | 0.82 | KDM4E (0.68) | KDM4EGAASMN1; SMN2HTTNCOA1 | |
| SCHEMBL890832 | 0.80 | KDM4E (0.73) | KDM4EGAASMN1; SMN2HTTNCOA1 | |
| SCHEMBL2438920 | 0.80 | KDM4E (0.73) | KDM4EGAASMN1; SMN2HTTNCOA1 | |
| SCHEMBL995085 | 0.79 | GAA (0.77) | GAASMN1; SMN2HTTNCOA1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | disclosed |