Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 7/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.44 |
| ▸ | KCNJ5 | P48544 | 4/20 | 0.44 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3532225 | 0.84 | PTGS1 (0.48) | PTGS1PTK2KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL4722719 | 0.82 | PTGS1 (0.46) | PTGS1PTK2KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL3528696 | 0.82 | PTK2 (0.59) | PTGS1PTK2KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL4962638 | 0.79 | PTK2 (0.70) | PTK2CYP2D6CYP2C9 | |
| SCHEMBL3532390 | 0.79 | PTGS1 (0.44) | PTGS1PTK2KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL3534186 | 0.76 | TTBK1 (0.49) | PTGS1KCNJ6KCNJ5KCNJ3CYP3A4 | |
| SCHEMBL3536896 | 0.75 | PTK2 (0.46) | PTGS1PTK2KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL3538302 | 0.74 | PTGS1 (0.42) | PTGS1KCNJ6KCNJ5KCNJ3MAPT | |
| SCHEMBL2209824 | 0.73 | MAPK14 (0.62) | PTK2MEN1KMT2AMAPK1PTGS2 | |
| SCHEMBL3535023 | 0.73 | MAPK14 (0.43) | PTGS1PTK2KCNJ6KCNJ5KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207647-A1 | Pyrazole Derivatives Having Tyrosine Kinase Activity | MERCK PATENT GMBH (DE) | 2008-08-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207647-A1 | Pyrazole Derivatives Having Tyrosine Kinase Activity | TIE1, FER, ROS1 | PTGS1 2302/4885PTK2 152/4885KCNJ6 1555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.