Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 4/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4932383 | 0.84 | KMT2A (0.42) | CDC7KMT2ACHEK1HASPINCCNT1 | |
| Hydrochloric Acid SCHEMBL4967648 | 0.83 | KMT2A (0.41) | CDC7KMT2ACHEK1HASPINCCNT1 | |
| SCHEMBL4933700 | 0.82 | CDC7 (0.39) | CDC7KMT2ACHEK1HASPINCCNT1 | |
| Hydrochloric Acid SCHEMBL5089673 | 0.82 | ADORA2A (0.44) | CDC7KMT2ACHEK1HASPINCCNT1 | |
| Hydrochloric Acid SCHEMBL5095245 | 0.82 | ADORA2A (0.44) | CDC7KMT2ACHEK1HASPINCCNT1 | |
| Hydrochloric Acid SCHEMBL5089678 | 0.82 | ADORA2A (0.44) | CDC7KMT2ACHEK1HASPINCCNT1 | |
| SCHEMBL4934014 | 0.81 | KMT2A (0.40) | CDC7KMT2ACHEK1HASPINCCNT1 | |
| SCHEMBL4928120 | 0.79 | CHEK1 (0.41) | CDC7KMT2ACHEK1HASPINCCNT1 | |
| Hydrochloric Acid SCHEMBL5095330 | 0.79 | CDC7 (0.51) | CDC7KMT2ACHEK1HASPINCCNT1 | |
| Hydrochloric Acid SCHEMBL5095324 | 0.79 | CDC7 (0.51) | CDC7KMT2ACHEK1HASPINCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805175-B1 | NOVEL AZAINDOLE THIAZOLINONES AS ANTI-CANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2008-03-05 | — | — | EP | claimed |
| EP-1805175-B1 | NOVEL AZAINDOLE THIAZOLINONES AS ANTI-CANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2008-03-05 | — | — | EP | disclosed |
| US-7247727-B2 | Azaindole thiazolinones | HOFFMANN-LA ROCHE INC. (US) | 2007-07-24 | — | — | US | disclosed |
| US-7247727-B2 | Azaindole thiazolinones | HOFFMANN-LA ROCHE INC. (US) | 2007-07-24 | — | — | US | disclosed |