Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.54 |
| ▸ | CDK1 | P06493 | 6/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4250246 | 0.99 | CDK2 (0.53) | CDK2KCNH2CDK1JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL4254788 | 0.90 | CDK2 (0.51) | CDK2KCNH2CDK1JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL4246663 | 0.90 | CDK2 (0.50) | CDK2KCNH2CDK1JAK2JAK1 | |
| SCHEMBL13879011 | 0.88 | CDK2 (0.54) | CDK2KCNH2CDK1JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL4247697 | 0.87 | CDK2 (0.53) | CDK2KCNH2CDK1JAK2JAK1 | |
| SCHEMBL13879010 | 0.86 | CDK2 (0.54) | CDK2KCNH2CDK1JAK2JAK1 | |
| SCHEMBL4243943 | 0.85 | CDK2 (0.53) | CDK2KCNH2CDK1JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL4249706 | 0.85 | CDK2 (0.53) | CDK2KCNH2CDK1JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL4250789 | 0.84 | CDK2 (0.56) | CDK2KCNH2CDK1JAK2JAK1 | |
| Lithium Ion SCHEMBL4243939 | 0.84 | CDK2 (0.52) | CDK2KCNH2CDK1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945628-A1 | NEW PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY AS WELL AS THE USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER'S DISEASE | AstraZeneca AB (SE) | 2008-07-23 | — | — | EP | claimed |
| WO-2007040440-A1 | NEW PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY AS WELL AS THE USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER’S DISEASE | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |