Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.47 |
| ▸ | MARK3 | P27448 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.47 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964144 | 0.91 | AURKA (0.47) | AURKAKDRPLK4CHEK2ABL1 | |
| SCHEMBL4963661 | 0.88 | AURKA (0.51) | AURKAKDRPLK4CHEK2ABL1 | |
| SCHEMBL4965206 | 0.87 | AURKA (0.47) | AURKAKDRPLK4CHEK2ABL1 | |
| SCHEMBL4962187 | 0.87 | AURKA (0.47) | AURKAKDRPLK4CHEK2ABL1 | |
| SCHEMBL5860874 | 0.87 | LCK (0.56) | AURKAKDRPLK4CHEK2ABL1 | |
| SCHEMBL4966578 | 0.86 | AURKA (0.44) | AURKAKDRPLK4CHEK2ABL1 | |
| SCHEMBL4965843 | 0.81 | AURKA (0.46) | AURKAKDRPLK4CHEK2ABL1 | |
| SCHEMBL4965211 | 0.80 | AURKA (0.41) | AURKAKDRPLK4CHEK2ABL1 | |
| SCHEMBL4963742 | 0.80 | AURKA (0.48) | AURKAKDRPLK4CHEK2ABL1 | |
| SCHEMBL4964918 | 0.79 | AURKA (0.41) | AURKAKDRPLK4CHEK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585749-B1 | DIAZEPINOINDOLE DERIVATIVES AS KINASE INHIBITORS | PFIZER (US) | 2008-08-13 | — | — | EP | claimed |