Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 9/20 | 0.77 |
| ▸ | TP53 | P04637 | 8/20 | 0.77 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966721 | 0.96 | MDM2 (0.70) | MDM2TP53ACHEHSD11B1ADAMTS5 | |
| SCHEMBL3964720 | 0.93 | MDM2 (0.86) | MDM2TP53ACHEHSD11B1 | |
| SCHEMBL3969567 | 0.89 | MDM2 (0.80) | MDM2TP53ADAMTS5MEN1KMT2A | |
| SCHEMBL3968027 | 0.88 | TP53 (0.71) | MDM2TP53MEN1KMT2A | |
| SCHEMBL3971402 | 0.87 | MDM2 (1.00) | MDM2TP53ACHEMEN1KMT2A | |
| SCHEMBL3967494 | 0.87 | MDM2 (0.83) | MDM2TP53ACHEADAMTS5ALDH1A1 | |
| SCHEMBL3964717 | 0.86 | MDM2 (0.68) | MDM2TP53ADAMTS5 | |
| SCHEMBL3969681 | 0.86 | MDM2 (0.69) | MDM2TP53 | |
| SCHEMBL8248411 | 0.85 | MDM2 (0.67) | MDM2TP53ADAMTS5MEN1KMT2A | |
| SCHEMBL3964590 | 0.85 | MDM2 (0.82) | MDM2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008543917-A | — | — | 2008-12-04 | — | — | JP | claimed |
| EP-1896412-A2 | OXINDOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-03-12 | — | — | EP | claimed |
| WO-2006136606-A2 | OXINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-28 | — | — | WO | claimed |
| EP-1896412-A2 | OXINDOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006136606-A2 | OXINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-28 | — | — | WO | disclosed |