Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 2/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 7/20 | 0.41 |
| ▸ | STAT3 | P40763 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3422693 | 0.95 | MEN1 (0.51) | MAPK10MAPK9MEN1KMT2AL3MBTL1 | |
| SCHEMBL3422697 | 0.95 | MEN1 (0.51) | MAPK10MAPK9MEN1KMT2AL3MBTL1 | |
| SCHEMBL3423285 | 0.88 | MEN1 (0.53) | MAPK10MAPK9MEN1KMT2AL3MBTL1 | |
| SCHEMBL3423282 | 0.88 | MEN1 (0.53) | MAPK10MAPK9MEN1KMT2AL3MBTL1 | |
| SCHEMBL2961366 | 0.85 | MEN1 (0.53) | MAPK10MAPK9MEN1KMT2AL3MBTL1 | |
| SCHEMBL2961370 | 0.85 | MEN1 (0.53) | MAPK10MAPK9MEN1KMT2AL3MBTL1 | |
| SCHEMBL13239782 | 0.85 | MAPK10 (0.48) | MAPK10MAPK9MEN1KMT2AL3MBTL1 | |
| SCHEMBL2969159 | 0.84 | MAPK10 (0.46) | MAPK10MAPK9MEN1KMT2AL3MBTL1 | |
| SCHEMBL2969155 | 0.84 | MAPK10 (0.46) | MAPK10MAPK9MEN1KMT2AL3MBTL1 | |
| SCHEMBL3420026 | 0.84 | MEN1 (0.49) | MAPK10MAPK9MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896484-A2 | TETRAHYDROPYRIDOTHIOPHENES FOR USE IN THE TREATMENT OF CANCER | Nycomed GmbH (DE) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006125813-A2 | TETRAHYDROPYRIDOTHIOPHENES FOR USE IN THE TREATMENT OF CANCER | NYCOMED GMBH (DE) | 2006-11-30 | — | — | WO | disclosed |