Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 12/20 | 0.60 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA4 | P22748 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 2/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963329 | 1.00 | FLT3 (0.60) | FLT3AKT1PAK1CA12CA1 | |
| SCHEMBL4959852 | 0.91 | FLT3 (0.73) | FLT3AKT1PAK1CA12CA1 | |
| SCHEMBL4959842 | 0.91 | FLT3 (0.73) | FLT3AKT1PAK1CA12CA1 | |
| SCHEMBL4960975 | 0.90 | FLT3 (0.73) | FLT3AKT1PAK1CA12CA1 | |
| SCHEMBL5921852 | 0.86 | FLT3 (0.78) | FLT3PAK1PDGFRBKIT | |
| SCHEMBL5921851 | 0.86 | FLT3 (0.78) | FLT3PAK1PDGFRBKIT | |
| SCHEMBL4960587 | 0.85 | FLT3 (0.78) | FLT3PAK1PDGFRBKIT | |
| SCHEMBL4968133 | 0.79 | PDE10A (0.56) | KIT | |
| SCHEMBL4966365 | 0.77 | PDE10A (0.56) | KIT | |
| SCHEMBL4959947 | 0.75 | FLT3 (0.72) | FLT3AKT1PAK1PDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896029-A1 | AMINOPYRIMIDINES AS KINASE MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006135644-A1 | AMINOPYRIMIDINES AS KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |