⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963433 | 1.00 | — | — | |
| SCHEMBL1771125 | 0.93 | MAPT (0.33) | — | |
| SCHEMBL5265626 | 0.91 | USP2 (0.35) | — | |
| SCHEMBL14444691 | 0.87 | MAPT (0.38) | — | |
| SCHEMBL997153 | 0.84 | — | — | |
| SCHEMBL31505845 | 0.84 | — | — | |
| SCHEMBL13243216 | 0.84 | — | — | |
| SCHEMBL25902382 | 0.82 | USP2 (0.37) | — | |
| SCHEMBL19257468 | 0.81 | MAPT (0.40) | — | |
| SCHEMBL1521343 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735324-B1 | PREPARATION OF P-CHIROGENIC PHOSPHOLANES AND THEIR USE IN ASYMETRIC SYNTHESIS | WARNER LAMBERT CO (US) | 2008-08-20 | — | — | EP | disclosed |
| US-7390931-B2 | Preparation of P-chirogenic phospholanes and their use in asymmetric synthesis | PFIZER INC. (US) | 2008-06-24 | — | — | US | disclosed |
| EP-1735324-A1 | PREPARATION OF P-CHIROGENIC PHOSPHOLANES AND THEIR USE IN ASYMETRIC SYNTHESIS | Warner-Lambert Company LLC (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005095424-A1 | PREPARATION OF P-CHIROGENIC PHOSPHOLANES AND THEIR USE IN ASYMETRIC SYNTHESIS | WARNER-LAMBERT COMPANY LLC (US) | 2005-10-13 | — | — | WO | disclosed |
| US-20050222464-A1 | Preparation of P-chirogenic phospholanes and their use in asymmetric synthesis | HOGE GARRETT S II | 2005-10-06 | — | — | US | disclosed |