Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 2/20 | 0.43 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.43 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4994288 | 0.99 | SLC6A2 (0.69) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL4996344 | 0.83 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL4992412 | 0.83 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL5001368 | 0.83 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL5001159 | 0.83 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL3732482 | 0.83 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL5001133 | 0.83 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL14115686 | 0.83 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| SCHEMBL14115529 | 0.83 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 | |
| Hydrochloric Acid SCHEMBL5000948 | 0.82 | SLC6A2 (0.97) | SLC6A2SLC6A4SLC6A3CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200556-A1 | Amine Compounds And Inhibiting Neurotrasmitter Reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2008-08-21 | — | — | US | disclosed |
| EP-1791806-A4 | AMINE COMPOUNDS AND INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1791806-A2 | AMINE COMPOUNDS AND INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2007-06-06 | — | — | EP | disclosed |
| WO-2005120200-A2 | AMINE COMPOUNDS AND INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2005-12-22 | — | — | WO | disclosed |