Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.54 |
| ▸ | CTSD | P07339 | 7/20 | 0.50 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579463 | 0.91 | BACE1 (0.50) | BACE1CTSDBACE2 | |
| SCHEMBL4961340 | 0.89 | BACE1 (0.64) | BACE1CTSDBACE2 | |
| SCHEMBL4964180 | 0.88 | BACE1 (0.61) | BACE1CTSDBACE2 | |
| SCHEMBL4964676 | 0.87 | BACE1 (0.67) | BACE1CTSDBACE2 | |
| SCHEMBL4964254 | 0.86 | BACE1 (0.62) | BACE1CTSDBACE2 | |
| SCHEMBL4962716 | 0.86 | BACE1 (0.51) | BACE1CTSDBACE2 | |
| SCHEMBL8377039 | 0.85 | BACE1 (0.71) | BACE1CTSDBACE2 | |
| SCHEMBL8377038 | 0.85 | BACE1 (0.71) | BACE1CTSDBACE2 | |
| SCHEMBL3579986 | 0.81 | BACE1 (0.59) | BACE1CTSDBACE2 | |
| SCHEMBL4962714 | 0.81 | BACE1 (0.63) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896454-A1 | AMlNO-5-(5-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR -SECRETASE MODULATION | Wyeth a Corporation of the State of Delaware (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007005366-A1 | AMlNO-5-(5-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR β-SECRETASE MODULATION | WYETH (US) | 2007-01-11 | — | — | WO | disclosed |