Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.78 |
| ▸ | RAB9A | P51151 | 7/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.78 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11276433 | 0.88 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL5186044 | 0.84 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL8616834 | 0.78 | KDM4E (0.59) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL1587424 | 0.78 | HDAC6 (0.55) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL711885 | 0.78 | NPC1 (0.91) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL30031669 | 0.77 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL8966500 | 0.77 | GAA (0.68) | NPC1RAB9ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL6127192 | 0.77 | KDM4E (0.89) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL4578939 | 0.77 | KDM4E (0.77) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL4578943 | 0.77 | KDM4E (0.77) | NPC1RAB9ASMN1; SMN2MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904472-A1 | THIOPHENE COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | Nissan Chemical Industries, Ltd. (JP) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007010954-A1 | THIOPHENE COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2007-01-25 | — | — | WO | disclosed |