Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | METAP2 | P50579 | 1/20 | 0.58 |
| ▸ | METAP1 | P53582 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | GCK | P35557 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27702357 | 0.88 | NPC1 (0.72) | NPC1CYP1A2RAB9AALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL27891481 | 0.87 | NPC1 (0.70) | NPC1CYP1A2RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL27891117 | 0.84 | NPC1 (0.63) | NPC1CYP1A2RAB9AALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL27908386 | 0.82 | NPC1 (0.61) | NPC1CYP1A2RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL27622181 | 0.78 | NPC1 (0.66) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5206561 | 0.78 | CYP1A2 (1.00) | NPC1CYP1A2RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL3278951 | 0.78 | CYP1A2 (0.73) | NPC1CYP1A2RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL11862403 | 0.77 | MEN1 (0.61) | NPC1CYP1A2RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4965216 | 0.77 | CYP1A2 (0.63) | NPC1CYP1A2RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL24072353 | 0.77 | CYP3A4 (0.81) | NPC1CYP1A2RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877391-A1 | PRO-DRUGS OF N-THIAZOL-2YL-BENZAMIDE DERIVATIVES | H. Lundbeck A/S (DK) | 2008-01-16 | — | — | EP | claimed |
| WO-2006114093-A1 | PRO-DRUGS OF N-THIAZOL-2YL-BENZAMIDE DERIVATIVES | H. LUNDBECK A/S (DK) | 2006-11-02 | — | — | WO | claimed |