Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 1.00 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.84 |
| ▸ | STK25 | O00506 | 1/20 | 0.84 |
| ▸ | CIT | O14578 | 1/20 | 0.84 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.84 |
| ▸ | GAK | O14976 | 1/20 | 0.84 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.84 |
| ▸ | JAK2 | O60674 | 1/20 | 0.84 |
| ▸ | STK17B | O94768 | 1/20 | 0.84 |
| ▸ | STK10 | O94804 | 1/20 | 0.84 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.84 |
| ▸ | ABL1 | P00519 | 1/20 | 0.84 |
| ▸ | LCK | P06239 | 1/20 | 0.84 |
| ▸ | FYN | P06241 | 1/20 | 0.84 |
| ▸ | FES | P07332 | 1/20 | 0.84 |
| ▸ | CSF1R | P07333 | 1/20 | 0.84 |
| ▸ | YES1 | P07947 | 1/20 | 0.84 |
| ▸ | LYN | P07948 | 1/20 | 0.84 |
| ▸ | MET | P08581 | 1/20 | 0.84 |
| ▸ | HCK | P08631 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965396 | 1.00 | EGFR (1.00) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL14925319 | 0.93 | EGFR (1.00) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL14925603 | 0.93 | EGFR (1.00) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL6466768 | 0.93 | EGFR (0.86) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL5499556 | 0.93 | EGFR (0.86) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL5499558 | 0.93 | EGFR (0.86) | EGFRERBB2STK25CITCHEK1 | |
| Hydrochloric Acid SCHEMBL2024049 | 0.92 | EGFR (0.99) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL5496335 | 0.92 | EGFR (1.00) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL5496337 | 0.92 | EGFR (1.00) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL17559179 | 0.91 | EGFR (0.84) | EGFRERBB2STK25CITCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130116206-A1 | QUINOLINE DERIVATIVES USED AS PET IMAGING AGENTS | IMPERIAL INNOVATIONS LIMITED (GB) | 2013-05-09 | — | — | US | disclosed |
| EP-1883630-A2 | METHODS OF SYNTHESIZING 6-ALKYLAMINOQUINOLINE DERIVATIVES | Wyeth (US) | 2008-02-06 | — | — | EP | disclosed |
| WO-2006127203-A2 | METHODS OF SYNTHESIZING 6-ALKYLAMINOQUINOLINE DERIVATIVES | WYETH (US) | 2006-11-30 | — | — | WO | disclosed |
| US-20060270670-A1 | Methods of synthesizing 6-alkylaminoquinoline derivatives | WYETH | 2006-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116206-A1 | QUINOLINE DERIVATIVES USED AS PET IMAGING AGENTS | ERBB2, EGFR, ERBB4 | EGFR 2/4885ERBB2 1/4885STK25 498/4885 |
| US-20060270670-A1 | Methods of synthesizing 6-alkylaminoquinoline derivatives | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, RECQL, NQO2 | EGFR 591/4885ERBB2 662/4885STK25 3019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.