Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 16/20 | 0.61 |
| ▸ | CCR3 | P51677 | 16/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 16/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969082 | 0.89 | HRH1 (0.65) | HRH1CCR3KCNH2AR | |
| SCHEMBL4968203 | 0.88 | HRH1 (0.63) | HRH1CCR3KCNH2AR | |
| SCHEMBL4969463 | 0.88 | HRH1 (0.63) | HRH1CCR3KCNH2AR | |
| SCHEMBL4967374 | 0.87 | HRH1 (0.80) | HRH1CCR3KCNH2 | |
| SCHEMBL4967289 | 0.86 | HRH1 (0.61) | HRH1CCR3KCNH2AR | |
| SCHEMBL4965885 | 0.84 | HRH1 (0.65) | HRH1CCR3KCNH2AR | |
| SCHEMBL4968256 | 0.84 | HRH1 (0.64) | HRH1CCR3KCNH2AR | |
| SCHEMBL4966126 | 0.83 | HRH1 (0.63) | HRH1CCR3KCNH2AR | |
| SCHEMBL4968849 | 0.82 | HRH1 (0.63) | HRH1CCR3KCNH2AR | |
| SCHEMBL4967181 | 0.81 | HRH1 (0.54) | HRH1CCR3KCNH2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625114-B1 | Piperidine derivatives for the the treatment of chemokine or H1 mediated diseases | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | disclosed |