SCHEMBL496849

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL496562	0.87	PDE2A (0.48)	PDE2APDE10AMAPTTP53POLB
	SCHEMBL2828064	0.87	PDE2A (0.51)	PDE2AMAPTPOLBHTTENPP3
	SCHEMBL496524	0.86	PDE2A (0.53)	PDE2APDE10AMAPTTP53POLB
	SCHEMBL496633	0.85	PDE2A (0.51)	PDE2AMAPTPOLBHPGDMAPK1
	SCHEMBL496573	0.83	PDE2A (0.46)	PDE2AMAPTKAT2BSMN1; SMN2NPC1
	SCHEMBL496930	0.83	PDE2A (0.51)	PDE2AMAPTTP53SMN1; SMN2NPC1
	SCHEMBL497340	0.83	PDE2A (0.51)	PDE2AMAPTTP53KAT2BTSHR
	SCHEMBL496714	0.83	PDE2A (0.51)	PDE2AMAPTTP53POLBKAT2B
	Dimethylamine SCHEMBL496715	0.80	NPC1 (0.56)	PDE2AMAPTTP53SMN1; SMN2NPC1
	SCHEMBL497281	0.78	ABCG2 (0.46)	PDE2APOLBSMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.