SCHEMBL4969130

SCHEMBL4969130

Fc1cc[c]cc1OCCCN1CCOCC1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.67
HRH3 Q9Y5N1 5/20 0.52
MAPK1 P28482 2/20 0.52
CYP1A2 P05177 2/20 0.52
ALDH1A1 P00352 1/20 0.52
CHRM2 P08172 1/20 0.52
CHRM1 P11229 1/20 0.52
HTR2A P28223 1/20 0.52
SCN1A P35498 1/20 0.52
HTR2B P41595 1/20 0.52
KCNH2 Q12809 1/20 0.52
SCN2A Q99250 1/20 0.52
SIGMAR1 Q99720 1/20 0.52
SCN3A Q9NY46 1/20 0.52
USP2 O75604 1/20 0.51
LMNA P02545 1/20 0.51
EPHX2 P34913 4/20 0.50
HRH2 P25021 1/20 0.49
HRH1 P35367 1/20 0.49
CYP2D6 P10635 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3515962 0.83 TSHR (0.60) KDM4EHRH3MAPK1CYP1A2ALDH1A1
SCHEMBL18707283 0.82 KDM4E (0.57) KDM4EALDH1A1TSHR
SCHEMBL24997065 0.80 KDM4E (1.00) KDM4EHRH3MAPK1CYP1A2ALDH1A1
SCHEMBL1442766 0.80 HRH3 (0.69) HRH3MAPK1CYP1A2ALDH1A1CHRM2
SCHEMBL14742300 0.80 TSHR (0.63) KDM4EALDH1A1HTR2BTSHR
SCHEMBL3165091 0.78 HRH3 (0.58) KDM4EHRH3MAPK1CYP1A2ALDH1A1
SCHEMBL28549776 0.77 TSHR (0.49) KDM4EALDH1A1TSHR
SCHEMBL3514630 0.76 SYK (0.54) KDM4EALDH1A1HTR2BCYP2D6TSHR
SCHEMBL12448372 0.76 KDM4E (0.67) KDM4EHRH3MAPK1CYP1A2ALDH1A1
SCHEMBL4813435 0.75 CYP2D6 (0.56) KDM4EHRH3CYP1A2ALDH1A1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1981876-A1 TRIAZOLOANILINOPYRIMIDINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS Arrow Therapeutics Limited (GB) 2008-10-22 EP disclosed
WO-2007080401-A1 TRIAZOLOANILINOPYRIMIDINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS ARROW THERAPEUTICS LIMITED (GB) 2007-07-19 WO disclosed