Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 6/20 | 0.41 |
| ▸ | CA1 | P00915 | 6/20 | 0.41 |
| ▸ | CA2 | P00918 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965943 | 0.90 | TSHR (0.55) | TSHRLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL4979636 | 0.88 | TSHR (0.50) | TSHRLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL22928073 | 0.75 | TSHR (0.61) | TSHRLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL22928067 | 0.75 | TSHR (0.67) | TSHRLMNAKDM4EALDH1A1HPGD | |
| Ethyl Nicotinate SCHEMBL16432474 | 0.73 | TSHR (0.47) | TSHRLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL22928045 | 0.73 | TSHR (0.60) | TSHRLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL10693255 | 0.72 | TSHR (0.59) | TSHRLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL14009724 | 0.71 | TSHR (0.81) | TSHRLMNAPTPN1NR3C1FYN | |
| SCHEMBL14036045 | 0.71 | TSHR (0.81) | TSHRLMNAPTPN1NR3C1FYN | |
| SCHEMBL11263625 | 0.71 | TSHR (0.57) | TSHRLMNAKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957086-A2 | NICOTINOYL RIBOSIDE COMPOSITIONS AND METHODS OF USE | CORNELL RESEARCH FOUNDATION, INC. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007061798-A2 | NICOTINOYL RIBOSIDE COMPOSITIONS AND METHODS OF USE | CORNELL RESEARCH FOUNDATION, INC. (US) | 2007-05-31 | — | — | WO | disclosed |